Endoplaq™
Endoplaq is a dietary supplement that as part of a balanced dietary regimen and healthy lifestyle is helpful in maintaining normal heart function, regulating the functioning of homocysteine metabolism, and protecting blood lipids from oxidative stress.
Serving quantity: 1
Number of servings: 30
Lotand expiration date: 5282453 - January 2026
Endoplaq® is a dietary supplement of omega-3 fatty acids EPA and DHA from highly purified and concentrated fish oil, olive extract standardized in hydroxytyrosol and coenzyme Q10. Vitamin E, piperine, folic acid and vitamin B12 complete the formulation.
Endoplaq® protects blood lipids from oxidative stress and helps preserve endothelium while maintaining good cardiac function.
- Daily intake of 250 mg of EPA and DHA omega-3 fatty acids is helpful in maintaining normal heart function (1 capsule of Endoplaq)1.
- Olive polyphenols, particularlyhydroxytyrosol, possess antioxidant activity (protection of LDL from oxidative damage); moreover, it has been shown that olive polyphenols can penetrate into cells and their absorption is dose dependent, their antioxidant activity is already manifested at very small doses (≥ 5 mg die). Olive extract present in Endoplaq provides 10 mg/capsule of hydroxytyrosol
- Coenzyme Q10 is an oxidative reduction agent, critical for optimizing cellular energy production (in the form of adenosine triphosphate-ATP).
- Folic acid and vitamin B12 support the smooth functioning of homocysteine metabolism.
- Vitamin E contributes to the protection of cells from oxidative stress because it acts as a free radical neutralizer.
- Piperine promotes the absorption of all nutrients, especially coenzyme Q10.
Indications and methods of use
1 capsule daily to be taken preferably near a meal.
Contraindications
Do not use in cases of known hypersensitivity to any of the components of the product or other closely related substances from a chemical standpoint.
Undesirable effects
None known.
Warnings
Store the product in a cool, dry place away from light and heat sources. The end of validity date refers to the product properly stored, in unopened package. Do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age. Food supplements should not be understood as a substitute for a varied and balanced diet and a healthy lifestyle.
Package
Each package contains 30 soft capsules.
References
1 Regulation 432/2012 of the European Commission - https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2012:136:0001:0040:IT:PDF
| Average content of characterizing elements | For 1 soft capsule |
|---|---|
| Omega-3 Total EPA DHA | 456 mg 275 mg 137 mg |
| Coenzyme Q10 | 100 mg |
| Olive (Olea europea L.) fruit e.s. of which hydroxytyrosol | 110 mg 10 mg |
| Vitamin E | 12 mg (100% NRVs*) |
| Folic Acid | 300 μg (150% NRVs*) |
| Vitamin B12 | 2 μg (80% NRVs1) |
| Piper nigrum L. e.s. | 1 mg |
| *Reference Nutrient Values - NRV | |
Ingredients:
Fish oil titrated to 90% omega-3 in the form of triglycerides (EPA and DHA min. 80% in a 2:1 ratio); food-grade gelatin capsule; resistance agent: glycerol; coenzyme Q10; olive tree(Olea europaea L.) fruit e.s. titrated to 10% hydroxytyrosol; thickener: yellow beeswax; d-alpha tocopherol (Vitamin E); vegetable fats (shea, coconut); emulsifier: lecithin; coloring: iron oxides and hydroxides; cyanocobalamin (vitamin B12); piperine from black pepper(Piper nigrum L.) fruit; pteroylmonoglutamic acid (folic acid).
Allergens: fish.
GLUTEN-FREE product
U.G.A. supplements. Nutraceuticals comply with Good Manufacturing Practices ( GMP ) rules, a list of standards that regulates the methods, equipment, means and management of production to ensure quality standards. These standards are mainly used in the pharmaceutical and food fields.
Constant attention and monitoring throughout the entire production cycle enabled the company to obtain ISO9001 certification (a certification attesting to the quality of a company system).
U.G.A. Nutraceuticals is also a member of GOED (Global Organization for EPA and DHA Omega-3), a body whose mission is to globally disseminate knowledge of omega-3 supplements, promote ethical and quality standards, and support various organizations on information and safety.
Shipping to Italy
Shipping costs within the national border are calculated as follows:
- FREE for orders above € 20.00 via TNT courier;
- € 3 for orders under € 20.00 via TNT courier;
- €5 for orders handled through DHL;
Average delivery time is 24-48 working hours from the day of shipment.
Overseas shipping
We ship, by express courier, worldwide via UPS, DHL or FedEx. On average, delivery takes 72-96 hours. We normally process all orders within 24 hours.
Shipping costs to Europe are calculated as follows:
- €20 for orders up to €149.99
- € 30 for orders up to € 249.99;
- € 40 for orders of € 250.00 and above.
In the rest of the world:
- £30 for orders up to £149.99
- €40 for orders up to €249.99;
- € 50 for orders of € 250.00 and above.
For shipments outside the European Union, you may have to pay an import tax or customs duties. These fees are separate from shipping charges.
To get an idea of the final cost, the following site can be consulted.
Temperature-controlled shipping
Temperature-controlled shipping takes place in Eurodifarm's refrigerated vans, the same ones used by pharmaceutical distributors.
We are the first in Italy to adopt this distribution system for dietary supplements as well. All for the benefit of the customer at a small additional cost:
- €15 for orders from 0 to 5 kg
- € 30 for orders over 5 kg
Delivery times are longer than those of a regular courier service, particularly on islands, because it is necessary to ensure the cold chain and freshness of the product at every step.
The customer is contacted by phone before delivery to arrange a delivery time with the courier.
Average time for delivery: 4-10 working days.
Warning.
In order to ensure prompt delivery, it is important to give an address where there is always someone there during the day to receive the package, e.g., the concierge, office, etc.
RELATED PRODUCTS
The Benefits of Omega-3s
The properties of Omega-3s are useful as early as gestation, when they help the proper development of the baby's cardiovascular system, brain and eyes. And again to protect the heart, arteries, nervous system and eyesight, it is important to ensure adequate levels during the rest of life as well. Of all the possible benefits of Omega-3s that have been most studied, the best known relate to the heart:
- To the reduction of blood triglyceride levels after meals and on an empty stomach;
- to the increase in so-called "good" cholesterol (the HDL, High Density Lipoproteins);
- to antithrombotic properties that could help reduce the risk of serious cardiovascular events (such as heart attack and stroke);
- To an antiarrhythmic effect;
- to an anti-inflammatory action that by affecting the dilation of arteries could help fight hypertension, especially during old age.
FAQ
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At what age can you start taking Omegor supplements?+
In principle, there are no age limits for starting or stopping omega-3 fatty acid dietary supplementation. In any case, the capsules and thus the recommended doses are designed for healthy men of about 70 kg but can be adjusted individually according to weight, specific functional needs, and any disease states specific to the subject.
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How can the effects produced by omega-3s be measured?+
The main purpose of OMEGOR Omega-3 supplementation is to prevent a dietary deficit of essential fatty acids by going about restoring physiological levels of these essential substances in our cells. Our bodies are very greedy for these vital fatty acids. To evaluate the effects produced by Omega-3 OMEGOR, in addition to interpreting the beneficial signals sent by our body, one can measure the improvement of so-called "cardiac coherence" or even monitor the presence of these fatty acids in the blood. First, one could do a normal fasting plasma lipid test, to be repeated after two to three months of treatment, and calculate the ratio of triglycerides to "good" (HDL) cholesterol, i.e., (TG/HDL): simply take the value of triglycerides and divide it by that of HDL cholesterol. In some studies, it has been observed that a ratio of triglycerides to HDL of less than 2 indicates a lower relative risk of heart disease. It would be useful to evaluate the evolution of this value before and after the supplementation period by consulting with your primary care physician. In addition, there is a new blood test that measures the ratio of arachidonic acid to eicosapentaenoic acid (AA/EPA). It is advisable to perform this test two to three months after the start of treatment. Studies on the Japanese population, which has the highest average life span among industrialized countries, have shown that a value of this ratio between approximately 1 and 3 correlates with excellent functional balance and health status. Recently it has been highlighted by the work of Harris WS and von Schacky C that measurement of the amount of EPA+DHA , as the percentage of total fatty acids present in red blood cell membranes in the blood ("Omega-3 Index") can give important premonitory information of clinical relevance regarding the risk of death from cardiovascular disease.
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Can Omega-3s be helpful for multiple sclerosis?+
Results of studies that specifically measured the effect of Omega-3s on multiple sclerosis have shown that Omega-3s improve the symptoms of patients with the condition. This is generally true for all auto-immune diseases, contributing to a better balance of the immune system. While there are no particular side effects to be feared in using Omega-3s for multiple sclerosis, it should be emphasized that the results could be moderate but still potentially significant such as reducing the necessary doses of anti-inflammatory or immunosuppressive drugs after a few months of treatment; all clearly under the supervision of the treating physician.
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What are the effects of Omega-3 on cholesterol and triglycerides?+
At high dosages, EPA and DHA have a powerful and well-demonstrated triglyceride-lowering effect. Supplementation with EPA/DHA of 1 to 3 grams per day provides a quantifiable reduction in blood serum triglycerides. There is a dose-response relationship, that is, the greater the amount of EPA/DHA taken, the greater the triglyceride-reducing effect. In some studies, it has been observed that an amount of 1 gram of EPA+DHA taken regularly produces a decrease in triglycerides of about 20 percent in some subjects. A reduction on the order of 25-30% was obtained with a larger dose (>4 grams). EPA and DHA at the same time change other lipid parameters (LDL, VLDL, HDL). In particular, intake of about 3 grams produces an increase in HDL values (the "good" cholesterol) and a reduction, but more modestly, in total "bad" cholesterol values (VLDL + LDL).
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Can one become addicted to omega-3 supplements?+
EPA and DHA supplements are not drugs or artificial molecules, but rather dietary supplements that renew the body's essential fatty acid reserves in cases of dietary deficiency and/or increased need for these nutrients. Abrupt discontinuation of treatment has no adverse effect except the risk of letting physiological reserves gradually decline again in the absence of a diet sufficiently rich in Omega-3.
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Do omega-3s play a preventive role?+
First, it is important to differentiate the concept of primary prevention from that of secondary prevention. The latter refers to those patients who have already had an initial cardiovascular "alert." Most clinical trials carried out employing Omega-3 fatty acids have considered precisely this type of patient. In this regard, Omega-3s have been widely shown to reduce the risk of even sudden cardiovascular mortality (GISSI Prevention). Further studies, carried out in healthy patients without previous episodes of cardiac phenomena (primary prevention studies), have demonstrated a beneficial influence of Omega-3s with regard to normal cardiovascular function.
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Is taking omegor omega-3 supplements fattening?+
The short answer is no. In fact, each 1-gram capsule of OMEGOR Vitality has just over 10 calories. Three 1-gram capsules of OMEGOR Vitality therefore contain about 32 calories and that is the equivalent of half an apple. Several studies on rats suggest that Omega-3s actually reduce the formation and size of fat cells (adipocytes). Moreover, Omega-3s are mainly used as constituents of cell membranes, not for energy purposes. For these reasons, taking OMEGOR Vitality is not fattening; in fact, the opposite is true.
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What may be the side effects of omega-3?+
The most common side effect of Omega-3 supplements is the possible fishy aftertaste; however, this can easily be eliminated by using small tricks such as taking the capsules just before a meal and/or possibly splitting the doses. As an example, if you take three capsules a day, it is advisable to take one immediately before each main meal. In some people Omega-3s can speed up intestinal transit. During the first week of treatment it is rare but possible for stools to be soft and diarrheal episodes to occur; in this case simply reduce doses for one or two weeks as appropriate and then try the initial dose again to test for increased tolerability. In other, rarer cases, Omega-3s may facilitate the appearance of bruising since, like aspirin, they interfere with certain mechanisms of blood clotting (platelet aggregation). This is generally considered one of their main beneficial effects that results in reducing the risk of heart attack or cerebrovascular complications. It could, however, pose a problem for those people predisposed to bruising or who use anti-coagulant drugs of which Omega-3s could potentiate the effect. In such cases, it is advisable to consult your doctor before starting Omega-3 supplementation.
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Can Omega-3s be taken during pregnancy?+
A Danish study suggests that women with an Omega-3-rich diet during pregnancy deliver babies with "healthier" birth weights and are less often subject to premature births. Omega-3s are known to play an important role in the development of the nervous system of the fetus and infant, and women with an Omega-3-deficient diet during pregnancy face an increased risk of postpartum depression Authoritative confirmation of the need to ensure adequate intakes of docosahexaenoic acid (DHA) during this delicate phase came recently (September 2005) from the European Consensus Conference on Recommendations for Polyunsaturated Fatty Acids for Pregnant and Lactating Women (PERILIP), whose aim was to improve guidelines on nutrition during the period of pregnancy and growth of the unborn child. Experts in nutrition, placental development and function, obstetrics and neonatology, led by Dr. Berthold Koletzko and Dr. Irene Cetin, concluded the work by recommending a minimum daily intake of 200mg DHA for pregnant and breastfeeding women. PERILIP highlighted the fact that intakes of up to 1g of DHA or 2.7g of long-chain omega-3 poly-unsaturated fatty acids (n-3 LCPUFAs) have been shown to be free of relevant side effects in various clinical trials. This recommendation may soon become part of the new official guidelines of the EU, which, among other things, funded the work of the aforementioned PERILIP conference.
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Could excessive omega-3 consumption be dangerous?+
Starting with the fact that overconsumption of Omega-3 is considered to be those who have a diet already rich in Omega-3 combined with appropriate dietary supplementation. In such a situation, there is no risk from overdose. Suffice it to say that Eskimos living in Northern Quebec in Canada consume up to 16 grams of fish oil per day, and to date no adverse effect caused by such a dose of Omega-3 has been observed.